Manchester United’s air of optimism was punctured as Alex Iwobi’s 97th minute winner handed Fulham their first win at Old Trafford since 2003, while Aston Villa surged clear in fourth by beating Nottingham Forest 4-2 on Saturday.
The completion of Jim Ratcliffe’s minority stake in United this week and a spell of good form had brought hope of a fresh start for the Red Devils.
United had won their previous four Premier League games to rekindle hope of qualifying for next season’s Champions League, but a 2-1 defeat leaves them eight points adrift of Villa.
Ratcliffe revealed his ambition to topple Manchester City and Liverpool at the top of the English game within three years.
But the work that lies ahead of the British billionaire on and off the field was exposed as Fulham dominated a ragged United for long spells.
Rodrigo Muniz came closest to opening the scoring before half-time when he hit the post.
Fulham finally took one of their chances midway through the second half when Calvin Bassey lashed home his first goal for the Cottagers from a corner.
United looked to have snatched a point against the run of play late on when Harry Maguire tapped in after Bernd Leno spilled Bruno Fernandes’ effort.
But there was another twist in the tale as Fulham secured their first away win since the opening day of the season.
Adama Traore left Maguire trailing in his wake before teeing up Iwobi to curl inside Andre Onana’s near post.